Molecular chaperones: small heat shock proteins in the limelight |
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Authors: | van den IJssel P Norman D G Quinlan R A |
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Institution: | Department of Biochemistry, University of Dundee, UK. |
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Abstract: | Small heat shock proteins have been the Cinderellas of the molecular chaperone world, but now the crystal structure of a small heat shock protein has been solved and mutation of two human homologues implicated in genetic disease. Intermediate filaments appear to be one of the key targets of their chaperone activity. |
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