Prediction of protein secondary structure based on physical theory. Histones |
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| Authors: | O B Ptitsyn A V Finkelstein |
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| Institution: | Institute of Protein Research, Academy of Sciences of the USSR, Moscow. |
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| Abstract: | Secondary structures of histones H1, H2A, H2B, H3, H4 and H5 have been calculated by the computer program ALB based on a molecular theory of protein secondary structure. The predicted secondary structures of all histones are predominantly alpha-helical. The calculated secondary structure of linker histones H1 and H5 is close to that previously obtained from two-dimensional NMR data. For each of the core histones (H2A, H2B, H3, H4) one long alpha-helix and several short ones have been predicted. These long helices can be identified with rods in the low-resolution electron density map. |
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