Polyprenylated Xanthones from Garcinia lancilimba Showing Apoptotic Effects against HeLa‐C3 Cells |
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| Authors: | Quan‐Bing Han Hong‐Lei Tian Nian‐Yun Yang Chun‐Feng Qiao Jing‐Zheng Song Donald C. Chang Kathy Q. Luo Hong‐Xi Xu |
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| Affiliation: | 1. Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, N.?T., Hong Kong, P.?R. China (phone: +852‐3406‐2873;2. fax: +852‐3551‐7333);3. Bioengineering Graduate Program, Department of Chemical Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, P.?R. China;4. Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, P.?R. China |
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| Abstract: | Three new prenylated xanthones, 1 – 3 , along with ten known compounds, were isolated from the stem bark of Garcinia lancilimba. Their structures were elucidated by extensive spectroscopic analysis, including 1D‐ and 2D‐NMR spectra, as well as HR‐MS experiments. Some of these compounds showed apoptotic effects or growth‐inhibition effects against HeLa cells expressing a caspase sensor protein. |
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| Keywords: | Garcinia lancilimba Xanthones Apoptotic effect Growth‐inhibition activity |
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