New Phytotoxic Metabolites from Pestalotiopsis sp. HC02, a Fungus Residing in Chondracris rosee Gut |
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| Authors: | Ying?Lao Zhang Hui?Ming Ge Fang Li Yong?Chun Song Ren?Xiang Tan |
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| Institution: | 1. Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, P. R. China, (phone: +86‐25‐8359‐5103;2. fax: +86‐25‐8368‐6559) |
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| Abstract: | Two new phytotoxic γ‐lactones, pestalotines A and B ( 1 and 2 , resp.), along with 4‐oxo‐4H‐pyran‐3‐acetic acid ( 3 ) and 6‐hydroxyramulosin (=3,4,4a,5,6,7‐hexahydro‐6,8‐dihydroxy‐3‐methyl‐1H‐2‐benzopyran‐1‐one; 4 ), were isolateded from the culture of Pestalotiopsis sp. HC02, a fungus residing in the Chondracris rosee gut. Structures of the new metabolites were elucidated on the basis of their IR, NMR, and MS data. Pestalotines A and B ( 1 and 2 , resp.) significantly inhibited the radical growth of Echinochloa crusgalli with IC50 values of 1.85×10?4 and 2.50×10?4 M , respectively, comparable to that of 2‐(2,4‐dichlorophenoxy)acetic acid (0.94×10?4 M ) used as a positive control. |
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| Keywords: | Pestalotiopsis species Fungi Chondracris rosee Pestalotines A and B Metabolites Phytotoxic activity |
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