Synthesis,Characterization, and Antifungal Activity of Boron‐Containing Thiosemicarbazones |
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| Authors: | Justin W. Hicks Christian B. Kyle Christopher M. Vogels Susan L. Wheaton Felix J. Baerlocher Andreas Decken Stephen A. Westcott |
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| Affiliation: | 1. Department of Chemistry, Mount Allison University, Sackville, NB E4L?1G8, Canada, (phone: +1‐506‐364‐2372;2. fax: +1‐506‐364‐2313);3. Department of Biology, Mount Allison University, Sackville, NB E4L?1G7, Canada;4. Department of Chemistry, University of New Brunswick, Fredericton, NB E3B?5A3, Canada |
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| Abstract: | Addition of thiosemicarbazide, 4‐allylthiosemicarbazide, and 4‐phenylthiosemicarbazide to (formylphenyl)boronic acids affords a series of thiosemicarbazones containing boronic acids. Addition of 2‐formylphenylboronic acid to the thiosemicarbazides gave the corresponding cyclic 2,3,1‐benzodiazaborines. All new compounds have been investigated for potential antifungal activity. |
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| Keywords: | Thiosemicarbazones Antifungal activity Boron compounds Boronic acids Diazaborines X‐Ray crystallography |
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