|
|||||
|
|
Tau epitope display in progressive supranuclear palsy and corticobasal degeneration |
|
| Authors: | Berry R W Sweet A P Clark F A Lagalwar S Lapin B R Wang T Topgi S Guillozet-Bongaarts A L Cochran E J Bigio E H Binder LI |
| Institution: | 1. Northwestern University, Department of Cell and Molecular Biology, Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL, 60611, USA 2. Northwestern University, Cognitive Neurology and Alzheimer's Disease Center, Feinberg School of Medicine, Chicago, IL, USA 3. Rush University Medical Center, Department of Pathology and Department of Neurological Sciences, Chicago, IL, 60012, USA |
| Abstract: | Filamentous aggregates of the protein tau are a prominent feature of Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). However, the extent to which the molecular structure of the tau in these aggregates is similar or differs between these diseases is unclear. We approached this question by examining these disorders with a panel of antibodies that represent different structural, conformational, and cleavage-specific tau epitopes. Although each of these antibodies reveals AD pathology, they resolved into three classes with respect to PSP and CBD: AD2 and Tau-46.1 stained the most tau pathology in all cases; Tau-1, 2, 5, and 12 exhibited variable reactivity; and Tau-66 and MN423 did not reveal any tau pathology. In addition, hippocampal neurofibrillary tangles in these cases showed a predominantly PSP/CBD-like, rather than AD-like, staining pattern. These results indicate that the patterns of the tau epitopes represented by this panel that reside in the pathological aggregates of PSP and CBD are similar to each other but distinct from that of AD. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |