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Topical anti-inflammatory activity of boropinic acid and its natural and semi-synthetic derivatives |
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| Authors: | Epifano Francesco Sosa Silvio Tubaro Aurelia Marcotullio M Carla Curini Massimo Genovese Salvatore |
| Institution: | a Dipartimento di Scienze del Farmaco, Università ‘G. D’Annunzio’ Chieti-Pescara, Via dei Vestini 31, Chieti Scalo (CH) 66013, Italy b Dipartimento dei Materiali e delle Risorse Naturali, Università di Trieste, Via A. Valerio 6, 34127 Trieste, Italy c Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Organica, Università degli Studi di Perugia, Via del Liceo, Perugia 06123, Italy |
| Abstract: | Boropinic acid is a natural isopentenyloxycinnamic acid extracted from the aerial parts of Boronia pinnata Sm. (Rutaceae) with soybean 5-lipoxygenase inhibitory activity. In this paper the topical anti-inflammatory activity of boropinic acid and some of its natural and semi-synthetic derivatives was evaluated using the Croton oil ear test in mice as a model of acute inflammation. Some of the tested compounds (15, 17, 19, 20) revealed an effect comparable (ID50 = 0.18 ÷ 0.72 μmol/cm2) to that of the reference drug indomethacin (ID50 = 0.23 μmol/cm2), a non-steroidal anti-inflammatory drug. |
| Keywords: | Anti-inflammatory activity Boropinic acid Croton oil ear test Prenyloxycinnamic acids Prenyloxyphenylpropanoids |
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