Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta: Secondary structure, antimicrobial activity, and mammalian cell toxicity |
| |
| Authors: | Leite José Roberto S A Brand Guilherme D Silva Luciano P Kückelhaus Selma A S Bento Wilian R C Araújo Antonio L T Martins Graciella R Lazzari Andréia M Bloch Carlos |
| |
| Affiliation: | Laboratório de Espectrometria de Massa, Empresa Brasileira de Pesquisa Agropecuária - Recursos Genéticos e Biotecnologia, Esta??o Parque Biológico, Final W5, Asa Norte, Brasília, DF, 70770-900, Brazil. jrleite@ufpi.br |
| |
| Abstract: | The present study reports the structural characteristics, the biological activities, and preliminary clinical investigations of three synthetic members of the dermaseptin family of antimicrobial peptides. The three peptides showed similar tendencies to form alpha-helical structures in non-polar media. The antimicrobial activity towards bacteria and fungi was determined in the micromolar concentration and the peptides did not influenced peritoneal cells viability. One of the peptides was intravenously administered in mice at concentrations similar to those of antibiotics employed in bacterial/fungal infections and it did not cause any detectable changes in cells and tissues. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
