Identification of the herboxidiene biosynthetic gene cluster in Streptomyces chromofuscus ATCC 49982 |
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Authors: | Shao Lei Zi Jiachen Zeng Jia Zhan Jixun |
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Affiliation: | Department of Biological Engineering, Utah State University, Logan, Utah, USA. |
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Abstract: | The 53-kb biosynthetic gene cluster for the novel anticholesterol natural product herboxidiene was identified in Streptomyces chromofuscus ATCC 49982 by genome sequencing and gene inactivation. In addition to herboxidiene, a biosynthetic intermediate, 18-deoxy-herboxidiene, was also isolated from the fermentation broth of S. chromofuscus ATCC 49982 as a minor metabolite. |
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