Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications |
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| Authors: | Lee K Ravi G Ji X D Marquez V E Jacobson K A |
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| Affiliation: | Molecular Recognition Section, LBC, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA. |
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| Abstract: | Novel methanocarba adenosine analogues, having the pseudo-ribose northern (N) conformation preferred at adenosine receptors (ARs), were synthesized and tested in binding assays. The 5'-uronamide modification preserved [N6-(3-iodobenzyl)] or enhanced (N6-methyl) affinity at A3ARs, while the 2'-deoxy modification reduced affinity and efficacy in a functional assay. |
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