Computing and visually analyzing mutual information in molecular co-evolution |
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Authors: | Sebastian Bremm Tobias Schreck Patrick Boba Stephanie Held Kay Hamacher |
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Affiliation: | 1.Interactive Graphics Systems, Dept. of Computer Science,Technische Universit?t Darmstadt,Germany;2.Bioinformatics & Theo. Biology, Dept. of Biology,Technische Universit?t Darmstadt,Germany |
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Abstract: | Background Selective pressure in molecular evolution leads to uneven distributions of amino acids and nucleotides. In fact one observes correlations among such constituents due to a large number of biophysical mechanisms (folding properties, electrostatics, ...). To quantify these correlations the mutual information -after proper normalization - has proven most effective. The challenge is to navigate the large amount of data, which in a study for a typical protein cannot simply be plotted. |
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