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Desmin expression in colorectal cancer stroma correlates with advanced stage disease and marks angiogenic microvessels |
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| Authors: | Georgia Arentz Tim Chataway Timothy J Price Zaipul Izwan Gemma Hardi Adrian G Cummins Jennifer E Hardingham |
| Affiliation: | (1) Department of Haematology-Oncology, The Queen Elizabeth Hospital, Woodville, SA, 5011, Australia;(2) Department of Physiology, University of Adelaide, Adelaide, SA, 5005, Australia;(3) Department of Physiology, Flinders University, Bedford Park, SA, 5042, Australia;(4) Department of Medicine, University of Adelaide, Adelaide, SA, 5005, Australia;(5) Department of Gastroenterology and Hepatology, The Queen Elizabeth Hospital, Woodville, SA, 5001, Australia |
| Abstract: | IntroductionBiomarkers that improve stratification of colorectal cancer patients for adjuvant therapy versus resection alone, or that are predictive of response to therapeutic agents, have the potential to greatly improve patient selection for such therapies. The aim was to determine proteins differentially expressed within the malignant epithelial glands and closely associated stromal elements compared to matched normal mucosa, and to characterise the over-expression of one such protein as a potential biomarker. |
| Keywords: | Colorectal cancer 2D DIGE desmin biomarker pericyte angiogenesis |
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