An Oral-Controlled Release Drug Delivery System for Liquid and Semisolid Drug Formulations |
| |
Authors: | Dorota Haznar-Garbacz Grzegorz Garbacz Friederike Eisenächer Sandra Klein Werner Weitschies |
| |
Institution: | (1) Department of Pharmaceutical Technology, Wroclaw Medical University, Szewska 38, 50 139 Wroclaw, Poland;(2) Institute of Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Strasse 17, 17489 Greifswald, Germany;(3) Institute of Pharmacy, University of Halle, Wolfgang-Langenbeck-Str. 4, 06120 Halle (Saale), Germany |
| |
Abstract: | A novel oral drug delivery system for the controlled release of liquid drugs, drug solutions, and semisolid drug preparations
is presented that is utilizing the constant vapor pressure of liquefied gas. The system is equipped with a capillary as an
element determining the drug delivery rate and contains a liquefied propellant with a suitable boiling point below human body
temperature. In the dissolution studies, polyacrylate gels of different viscosities containing paracetamol as model drug were
used. Zero-order release kinetics was obtained. The release rates were dependent on the gel viscosity. Besides, by gel viscosity,
the drug release rates could also be modified by changing the propellant type and the capillary parameters such as length
or diameter. Accordingly, the new system enables a wide range of drug delivery kinetics which can be modified in a case-by-case
basis in order to match the desired drug delivery characteristics. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|