Castration attenuates myelin repair following lysolecithin induced demyelination in rat optic chiasm: an evaluation using visual evoked potential, marker genes expression and myelin staining |
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Authors: | Sherafat Mohammad Amin Javan Mohammad Mozafari Sabah Mirnajafi-Zadeh Javad Motamedi Fereshteh |
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Institution: | (1) Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, P. O. Box: 14115-331, Tehran, Iran;(2) Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; |
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Abstract: | Multiple sclerosis (MS) is a demyelinating disease that affects the central nervous system. MS is the most common neurological
disorder in young adults with a greater incidence among females. Male gonadal hormones have a protective effect on neural
system development and myelin maturation. In this study, we investigate the effect of castration on lysolecithin-induced demyelination
and remyelination processes using visual evoked potentials, in addition to measuring the expressions of Olig2, MBP, Nogo-A
and GFAP mRNAs as oligodendrocyte or astrocyte markers; and histological assessments by myelin-specific staining. We observed
more expanded demyelination with delayed repair process in castrated rats. Expression levels of the aforementioned marker
genes confirmed histological and electrophysiological observations. Our results showed a pivotal role for endogenous male
hormones in the context of demyelinating insults. It may also account for the different prognosis of MS between male and female
genders and provide new insights for therapeutic treatments. |
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