A comparative analysis of exome capture |
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Authors: | Parla Jennifer S Iossifov Ivan Grabill Ian Spector Mona S Kramer Melissa McCombie W Richard |
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Institution: | (1) Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA |
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Abstract: | Background Human exome resequencing using commercial target capture kits has been and is being used for sequencing large numbers of individuals
to search for variants associated with various human diseases. We rigorously evaluated the capabilities of two solution exome
capture kits. These analyses help clarify the strengths and limitations of those data as well as systematically identify variables
that should be considered in the use of those data. |
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