|
|||||
|
|
The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis |
|
| Authors: | Anna-Karin H Ekwall Thomas Eisler Christian Anderberg Chunsheng Jin Niclas Karlsson Mikael Brisslert Maria I Bokarewa |
| Institution: | 1.Department of Rheumatology and Inflammation Research,Institute of Medicine, Sahlgrenska Academy, G?teborg University,G?teborg,Sweden;2.Department of Orthopaedics,Institute of Clinical Sciences, Sahlgrenska Academy, G?teborg University,G?teborg,Sweden;3.Division of Orthopaedics,Spenshult Hospital,Oskarstr?m,Sweden;4.Department of Medical Biochemistry and Cell Biology,Institute of Biomedicine, Sahlgrenska Academy, G?teborg University,G?teborg,Sweden |
| Abstract: | IntroductionActivated fibroblast-like synoviocytes (FLSs) in rheumatoid arthritis (RA) share many characteristics with tumour cells and are key mediators of synovial tissue transformation and joint destruction. The glycoprotein podoplanin is upregulated in the invasive front of several human cancers and has been associated with epithelial-mesenchymal transition, increased cell migration and tissue invasion. The aim of this study was to investigate whether podoplanin is expressed in areas of synovial transformation in RA and especially in promigratory RA-FLS. |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ | |