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Antifouling Bastadin Congeners Target Mussel Phenoloxidase and Complex Copper(II) Ions |
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| Authors: | Mirko Bayer Claire Hellio Jean-Philippe Maréchal Walter Frank Wenhan Lin Horst Weber Peter Proksch |
| Institution: | 1.Institut für Pharmazeutische Biologie und Biotechnologie,Heinrich-Heine-Universit?t Düsseldorf,Düsseldorf,Germany;2.Institut für Pharmazeutische und Medizinische Chemie,Heinrich-Heine-Universit?t Düsseldorf,Düsseldorf,Germany;3.School of Biological Sciences, King Henry Building,Portsmouth University,Portsmouth,UK;4.Institut für Anorganische Chemie und Strukturchemie,Heinrich-Heine-Universit?t Düsseldorf,Düsseldorf,Germany;5.State Key Laboratory of Natural and Biomimetic Drugs,Peking University,Beijing,People’s Republic of China;6.Caesar & Loretz GmbH,Hilden,Germany |
| Abstract: | Synthetically prepared congeners of sponge-derived bastadin derivatives such as 5,5′-dibromohemibastadin-1 (DBHB) that suppress the settling of barnacle larvae were identified in this study as strong inhibitors of blue mussel phenoloxidase that is involved in the firm attachment of mussels to a given substrate. The IC50 value of DBHB as the most active enzyme inhibitor encountered in this study amounts to 0.84 μM. Inhibition of phenoloxidase by DBHB is likely due to complexation of copper(II) ions from the catalytic centre of the enzyme by the α-oxo-oxime moiety of the compound as shown here for the first time by structure activity studies and by X-ray structure determination of a copper(II) complex of DBHB. |
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