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Sodium channel opening as a precursor to inactivation
Authors:L. Goldman
Affiliation:(1) Department of Physiology, School of Medicine, University of Maryland, 21201 Baltimore, Maryland, USA
Abstract:The time constant of the process producing the delay in Na inactivation development as determined by the two pulse method (taudelay) was extracted and compared to that of the slowest Na activation process tau3 for the INa during the conditioning pulse of that same determination. taudelay and two pulse inactivation tauc values were computer generated using a nonlinear least squares algorithm. tauh and single pulse inactivation tauh values were independently generated for each determination also with the aid of the computer using the same non-linear least squares algorithm. In one determination at 2 mV, tauc was 4.68 and taudelay 0.494 ms while tauh was 4.70 and tau3 0.491 ms for a tauc/tauh of 0.996 and a taudelay/tau3 of 1.006. Mean taudelay/tau3 from five determinations in four axons, both Cs and K perfused, and spanning a potential range of-27 to 2mV was 1.068. The precursor process to inactivation is channel opening. Some fraction of channels presumably inactivate via another route where prior channel opening is not required.
Keywords:Sodium currents  inactivation  kinetics  channel gating
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