DNA Repair Pathways in Trypanosomatids: from DNA Repair to Drug Resistance |
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| Authors: | Marie-Michelle Genois Eric R Paquet Marie-Claude N Laffitte Ranjan Maity Amélie Rodrigue Marc Ouellette Jean-Yves Masson |
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| Institution: | aGenome Stability Laboratory, CHU de Québec Research Center, Québec City, Québec, Canada;bDepartment of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Québec City, Québec, Canada;cCentre de Recherche en Infectiologie, Centre Hospitalier Université Laval, Québec, Québec, Canada |
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| Abstract: | SUMMARYAll living organisms are continuously faced with endogenous or exogenous stress conditions affecting genome stability. DNA repair pathways act as a defense mechanism, which is essential to maintain DNA integrity. There is much to learn about the regulation and functions of these mechanisms, not only in human cells but also equally in divergent organisms. In trypanosomatids, DNA repair pathways protect the genome against mutations but also act as an adaptive mechanism to promote drug resistance. In this review, we scrutinize the molecular mechanisms and DNA repair pathways which are conserved in trypanosomatids. The recent advances made by the genome consortiums reveal the complete genomic sequences of several pathogens. Therefore, using bioinformatics and genomic sequences, we analyze the conservation of DNA repair proteins and their key protein motifs in trypanosomatids. We thus present a comprehensive view of DNA repair processes in trypanosomatids at the crossroads of DNA repair and drug resistance. |
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