Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes |
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| Authors: | Brianna J Klein Marie-Eve Lalonde Jacques C?té Xiang-Jiao Yang Tatiana G Kutateladze |
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| Affiliation: | 1.Department of Pharmacology; University of Colorado School of Medicine; Aurora, CO USA;2.Laval University Cancer Research Center; Hôtel-Dieu de Québec (CHUQ); Quebec City, QC Canada;3.Rosalind and Morris Goodman Cancer Research Center; Departments of Medicine, Biochemistry, and Anatomy & Cell Biology; McGill University; Montréal, QC Canada |
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| Abstract: | The MOZ/MORF complexes represent an example of a chromatin-binding assembly whose recruitment to specific genomic regions and activity can be fine-tuned by posttranslational modifications of histones. Here we detail the structures and biological functions of epigenetic readers present in the four core subunits of the MOZ/MORF complexes, highlight the imperative role of combinatorial readout by the multiple readers, and discuss new research directions to advance our understanding of histone acetylation. |
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| Keywords: | MOZ MORF KAT6A KAT6B BRPF ING5 histone acetylation PHD reader |
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