Unequal evolutionary conservation of human protein interactions in interologous networks |
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| Authors: | Kevin R Brown Igor Jurisica |
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| Affiliation: | (1) Department of Medical Biophysics, University of Toronto, Toronto, M5G 1L7, Canada;(2) Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, M5G 1L7, Canada;(3) Department of Computer Science, University of Toronto, M5G 1L71 Toronto, Canada |
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| Abstract: | Background Protein-protein interaction (PPI) networks have been transferred between organisms using interologs, allowing model organisms to supplement the interactomes of higher eukaryotes. However, the conservation of various network components has not been fully explored. Unequal conservation of certain network components may limit the ability to fully expand the target interactomes using interologs. |
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