Affiliation: | 1. Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, College of life sciences, China Jiliang University, Hangzhou, China Contribution: Writing - original draft (supporting), Writing - review & editing (equal);2. Biological Control of Pest Research Unit, USDA-ARS, Stoneville, Mississippi Contribution: Writing - review & editing (supporting);3. Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, Michigan Contribution: Writing - review & editing (supporting);4. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia Contribution: Funding acquisition (equal), Writing - review & editing (supporting);5. Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, Michigan |
Abstract: | Aedes aegypti is the primary mosquito vector of dengue, yellow fever, Zika and chikungunya. Current strategies to control Ae. aegypti rely heavily on insecticide interventions. Pyrethroids are a major class of insecticides used for mosquito control because of their fast acting, highly insecticidal activities and low mammalian toxicity. However, Ae. aegypti populations around the world have begun to develop resistance to pyrethroids. So far, more than a dozen mutations in the sodium channel gene have been reported to be associated with pyrethroid resistance in Ae. aegypti. Co-occurrence of resistance-associated mutations is common in pyrethroid-resistant Ae. aegypti populations. As global use of pyrethroids in mosquito control continues, new pyrethroid-resistant mutations keep emerging. In this microreview, we compile pyrethroid resistance-associated mutations in Ae. aegypti in a chronological order, as they were reported, and summarize findings from functional evaluation of these mutations in an in vitro sodium channel expression system. We hope that the information will be useful for tracing possible evolution of pyrethroid resistance in this important human disease vector, in addition to the development of methods for global monitoring and management of pyrethroid resistance in Ae. aegypti. |