A robust soft sensor to monitor 1,3-propanediol fermentation process by Clostridium butyricum based on artificial neural network |
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Authors: | Ai-Hui Zhang Kai-Yi Zhu Xiao-Yan Zhuang Lang-Xing Liao Shi-Yang Huang Chuan-Yi Yao Bai-Shan Fang |
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Affiliation: | Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, China |
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Abstract: | With the aggravation of environmental pollution and energy crisis, the sustainable microbial fermentation process of converting glycerol to 1,3-propanediol (1,3-PDO) has become an attractive alternative. However, the difficulty in the online measurement of glycerol and 1,3-PDO creates a barrier to the fermentation process and then leads to the residual glycerol and therefore, its wastage. Thus, in the present study, the four-input artificial neural network (ANN) model was developed successfully to predict the concentration of glycerol, 1,3-PDO, and biomass with high accuracy. Moreover, an ANN model combined with a kinetic model was also successfully developed to simulate the fed-batch fermentation process accurately. Hence, a soft sensor from the ANN model based on NaOH-related parameters has been successfully developed which cannot only be applied in software to solve the difficulty of glycerol and 1,3-PDO online measurement during the industrialization process, but also offer insight and reference for similar fermentation processes. |
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Keywords: | 1, 3-propanediol artificial neural network Clostridium butyricum soft sensor |
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