Identification and determination of alpha-dicarbonyl compounds formed in the degradation of sugars |
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| Authors: | Usui Teruyuki Yanagisawa Satoshi Ohguchi Mio Yoshino Miku Kawabata Risa Kishimoto Junko Arai Yumi Aida Kaoru Watanabe Hirohito Hayase Fumitaka |
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| Affiliation: | Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University, Japan. |
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| Abstract: | The alpha-dicarbonyl compounds formed in the degradation of glucose and fructose were analyzed by HPLC using 2,3-diaminonaphthalene as derivatizing reagent, and identified as glucosone (GLUCO), 3-deoxyglucosone (3DG), 3-deoxyxylosone (3DX), tetrosone (TSO), triosone (TRIO), 3-deoxytetrosone (3DT), glyoxal (GO), and methylglyoxal (MGO). The results suggest that alpha-dicarbonyl compounds were formed from glucose via non-oxidative 3-deoxyglucosone formation and oxidative glucosone formation in glucose degradation. In addition, TRIO, GO, and MGO were also formed from glyceraldehyde as intermediate. The alpha-dicarbonyl compounds might be formed from glucose via these pathways in diabetes. |
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