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Ribonucleic Acid Synthesis in Plant Mitochondria: Effects of Some Inhibitors and Cyclic Nucleotides
Authors:BISWENDU B GOSWAMI  D K DUBE  S C ROY
Institution:Department of Biochemistry, University College of Science, 35, Ballygunge Circular Road, Calcutta 700019, India
Abstract:Mitochondria isolated from 48-h germinating Vigna sinensis (L.) Savi can incorporate 3H]uridine into acid-insoluble material. The incorporation is highly sensitive to rifampicin and partially so to ethidium bromide, two specific inhibitors of template function. The inhibitory effect of rifampicin can be partly counteracted by cyclic 3′:5′-AMP but not by cyclic 3′:5′-GMP, if they are allowed to interact with the synthetic system before the treatment with rifampicin. This indicates that cyclic AMP and rifampicin compete for a common site on the RNA polymerase responsible for DNA-dependent RNA synthesis. Inhibition by ethidium bromide is unaffected by prior nucleotide interaction with the system.
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