Interaction of mutant genes Fgf5go-Y, we, and wal changes the duration of hair growth cycles in mice |
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Authors: | A P Nesterova I I Nizamutdinov and B V Konyukhov |
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Abstract: | Mutant gene wallhaarig (wa) was acting as a modifier of the mutant gene waved alopecia (wal), substantially increasing hair loss rate in mice, as was previously shown in our laboratory. The current paper is devoted
to a study of mutant gene angora-Y (Fgf5
go-Y
), which had extended anagen stage of the first and second generations hair growth cycles in triple heterozygotes (Fgf5
go-Y
/Fgf5
go-Y
we/we wal/wal). First generation guard hair in triple homozygotes had their anagen stage 4 days longer than the same stage in double homozygotes
(+/+ we/we wal/wal). Hair loss started at a catagen stage in double homozygotes, while it started in triple homozygotes at the end of the same
stage or even in a telogen. Such mutant gene interaction in hair follicle morphogenesis led to a partial recovery of a body
hair coat in triple homozygotes. |
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Keywords: | |
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