Dual-mode potential oscillations on an immobilized acetylcholinesterase membrane system

We have studied by numerical stimulations the effects of varying external salt concentration on a multibarrier kinetic model of a synthetic membrane system bearing AChE and BSA. For certain parameters, we find a spiky high frequency modulation imposed on a bursting low frequency carrier. In the absence of added salt, oscillations with only one mode arise, consistent with the experimental result of Friboulet and Thomas. From this study, we suggest how periodic ionic permeability changes of ions may arise in excitable membranes.