Clinical significance of hWAPL polymorphisms in the risk of cervical carcinogenesis |
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Authors: | Osamu Nunobiki Daisuke Sano Sakae Hata Toshitada Ogasawara Masatsugu Ueda |
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Institution: | 1.Department of Medical Technology,Kobe Tokiwa University,Kobe,Japan;2.Department of Obstetrics and Gynecology,Okubo Hospital,Akashi,Japan;3.Cytopathology and Gynecology,Osaka Center for Cancer and Cardiovascular Disease Prevention,Osaka,Japan |
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Abstract: | To investigate the clinical significance of human wings apart-like (hWAPL) genetic polymorphisms in cervical carcinogenesis. hWAPL polymorphisms and human papillomavirus (HPV) types were examined in 175 cervical smears of exfoliated cervical cell samples using a real-time polymerase chain reaction system. A significant difference was detected in the frequency of the CC genotype between the HPV(+) low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL) groups Odds ratio 0.21, 95% confidence interval (CI) 0.0723–0.61; P = 0.0029]. A significant difference was noted in the frequency of the CC genotype between the high-risk HPV-positive LSIL and HSIL groups (odds ratio 0.2955, 95% CI 0.0893–0.9771; P = 0.0414). The CC genotype of hWAPL gene promoter polymorphism may be associated with cervical carcinogenesis. |
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