首页 | 本学科首页   官方微博 | 高级检索  
     


Bioactive Sesquiterpenoids and Diterpenoids from the Liverwort Bazzania albifolia
Authors:Na Liu  Dong‐Xiao Guo  Shu‐Qi Wang  Yan‐Yan Wang  Li Zhang  Gang Li  Hong‐Xiang Lou
Affiliation:1. Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, P.?R. China, (phone: +86‐531‐88382012;2. fax: +86‐531‐88382019)
Abstract:One undescribed 6,7‐secofusicoccane‐type diterpene, albifolione ( 1 ), and one new aromadendrane‐type sesquiterpenoid ketone, methyl 2‐oxoaromadendra‐1(10),3‐dien‐12‐oate ( 2 ), along with four known compounds, δ‐cuparenol ( 3 ), fusicoauritone ( 4 ), chiloscyphenols A and B ( 5 and 6 , resp.), were isolated from the liverwort Bazzania albifolia Horik. The structures and relative configurations of 1 and 2 were established unequivocally on the basis of spectroscopic data analysis. Preliminary bioassay revealed that compound 5 showed quite strong cytotoxicity against the human tumor cell line MCF‐7, with an IC50 value of 5.6 μM .
Keywords:Liverworts  Bazzania albifolia  Albifolione  Fusicoccane  Aromadendrane  Calamenene  Cytotoxic activity
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号