Bioactive Sesquiterpenoids and Diterpenoids from the Liverwort Bazzania albifolia |
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| Authors: | Na Liu Dong‐Xiao Guo Shu‐Qi Wang Yan‐Yan Wang Li Zhang Gang Li Hong‐Xiang Lou |
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| Institution: | 1. Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, P.?R. China, (phone: +86‐531‐88382012;2. fax: +86‐531‐88382019) |
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| Abstract: | One undescribed 6,7‐secofusicoccane‐type diterpene, albifolione ( 1 ), and one new aromadendrane‐type sesquiterpenoid ketone, methyl 2‐oxoaromadendra‐1(10),3‐dien‐12‐oate ( 2 ), along with four known compounds, δ‐cuparenol ( 3 ), fusicoauritone ( 4 ), chiloscyphenols A and B ( 5 and 6 , resp.), were isolated from the liverwort Bazzania albifolia Horik. The structures and relative configurations of 1 and 2 were established unequivocally on the basis of spectroscopic data analysis. Preliminary bioassay revealed that compound 5 showed quite strong cytotoxicity against the human tumor cell line MCF‐7, with an IC50 value of 5.6 μM . |
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| Keywords: | Liverworts Bazzania albifolia Albifolione Fusicoccane Aromadendrane Calamenene Cytotoxic activity |
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