Novel Zierane‐ and Guaiane‐Type Sesquiterpenes from the Root of Melicope denhamii |
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| Authors: | Ken‐ichi Nakashima Masayoshi Oyama Tetsuro Ito Joko Ridho Witono Dedy Darnaedi Toshiyuki Tanaka Jin Murata Munekazu Iinuma |
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| Institution: | 1. Laboratory of Pharmacognosy, Gifu Pharmaceutical University, 1‐25‐4 Daigaku‐nishi, Gifu 501?–?1196, Japan (phone: +81‐58‐230‐8100;2. fax: +81‐58‐230‐8105);3. Center for Plant Conservation, Bogor Botanical Garden, Indonesian Institute of Science (LIPI), Jalan Ir. H. Juanda 13, Bogor 16122, Indonesia;4. Research and Development Center for Biology, Indonesian Institute of Science (LIPI), Jalan Ir. H. Juanda 13, Bogor 16122, Indonesia;5. Laboratory of Natural Resources, Gifu Pharmaceutical University, 1‐25‐4 Daigaku‐nishi, Gifu 501‐1196, Japan;6. Botanical Gardens, Koishikawa, Graduate School of Science, University of Tokyo, 3‐7‐1 Hakusan, Bunkyo‐ku, Tokyo 112‐0001, Japan |
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| Abstract: | Two novel zierane‐type sesquiterpenes, named melicodenones A and B ( 1 and 2 , resp.), and three new guaiane‐type sesquiterpenes, named melicodenones C–E ( 3 – 5 ), were isolated from the root of Melicope denhamii (Seem. ) T. G. Hartley together with zierone ( 6 ). Their structures were established by extensive NMR‐spectroscopic analyses. Compounds 1 – 6 were tested for cytotoxicity using human colon cancer DLD‐1 cells, and melicodenone A ( 1 ) was found to exhibit moderate activity. |
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| Keywords: | Melicope denhamii Melicodenones A – E Sesquiterpenes Cytotoxic activity |
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