2,5‐Diketopiperazines from the Marine‐Derived Fungus Aspergillus fumigatus YK‐7 |
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| Authors: | Yu Wang Zhan‐Lin Li Jiao Bai Li‐Min Zhang Xin Wu Lin Zhang Yue‐Hu Pei Yong‐Kui Jing Hui‐Ming Hua |
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| Institution: | 1. Key Laboratory of Structure‐Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, No.?103 Road WenHua, Shenyang 110016, P.?R. China;2. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, No.?103 Road WenHua, Shenyang 110016, P.?R. China (phone/fax: +86‐24‐23986465);3. School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, No.?103 Road WenHua, Shenyang 110016, P.?R. China;4. Mount Sinai School of Medicine, New York, NY 10029, USA |
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| Abstract: | Five new diketopiperazines, prenylcyclotryprostatin B ( 1 ), 20‐hydroxycyclotryprostatin B ( 2 ), 9‐hydroxyfumitremorgin C ( 3 ), 6‐hydroxytryprostatin B ( 4 ), and spirogliotoxin ( 5 ), were isolated from the marine‐derived fungus Aspergillus fumigatus YK‐7, along with nine known compounds, 6 – 14 . Their structures were elucidated by spectroscopic methods, and their antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC‐3 cell lines were assessed in vitro. Compounds 10, 12 , and 13 exhibited significant cell growth‐inhibitory activities against U937 cell line, with the IC50 values of 1.8, 0.2, and 0.5 μM , respectively. |
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| Keywords: | Piperazine‐2 5‐diones Aspergillus fumigatus Marine natural products Fungi Antiproliferative activity |
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