Inverse correlation of intracellular calcium and cyclic AMP levels in renal cell carcinoma |
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| Authors: | Ujjawal Sharma Shrawan Kumar Singh Prasad Rajendra |
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| Affiliation: | 1. Department of Biochemistry, PGIMER, , Chandigarh, India;2. Department of Urology, PGIMER, , Chandigarh, India |
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| Abstract: | Renal cell carcinoma (RCC) is the most common renal tumour in adults. Altered levels of secondary messengers, that is, intracellular calcium and cyclic AMP (cAMP), have been implicated in the pathogenesis of various malignancies. In the present study, we measured levels of intracellular calcium and cAMP in RCC. The intracellular calcium level was significantly reduced, whereas the cAMP level was significantly augmented in RCC as compared with adjacent grossly normal renal parenchyma. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | alkaline phosphatase renal cell carcinoma secondary messengers intracellular calcium cAMP |
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