Relationship between serum arginase I and l-arginine or exhaled nitric oxide in asthma |
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| Authors: | Keiki Ogino Yasushi Obase Tatsuo Ito Masaki Fujimura Eri Eguchi Masayuki Kubo |
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| Institution: | 1. Department of Public Health, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;2. Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Okayama, Japan;3. Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan;4. Department of Molecular Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA;5. Respiratory Medicine, National Hospital Organization Nanao Hospital, Nanao, Japan |
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| Abstract: | The relationship between serum arginase I and serum l-arginine or fractional exhaled nitric oxide (FENO) was evaluated cross-sectionally in asthmatic patients. No sex difference was observed in the serum mean levels of arginase I and l-arginine or FENO. Arginase I and FENO were higher in patients 60 or younger years than in those over 60 years. Asthmatic patients were divided into three groups: no steroid therapy, inhalation steroid therapy, and oral steroid therapy. Arginase I, FENO and high-sensitivity-C-reactive protein (hs-CRP) were significantly lower in the inhalation steroid therapy group than in the no steroid therapy group. Correlations were observed between arginase I and FENO, l-arginine, hs-CRP, WBC, and age, and also between FENO and IgE, WBC, and age. A logistic regression analysis revealed the positive association of arginase I with FENO, and the negative association of l-arginine. FENO was positively associated with arginase I and IgE. These results indicated that serum arginase I might influence serum levels of l-arginine and FENO, and that IgE might influence FENO in asthmatic patients. |
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| Keywords: | Arginase I clinical study fractional exhaled nitric oxide (FENO) l-arginine" target="_blank">l-arginine |
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