Selective mobilization of CD14(+)CD16(+) monocytes by exercise |
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Authors: | Steppich B Dayyani F Gruber R Lorenz R Mack M Ziegler-Heitbrock H W |
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Institution: | Institute for Immunology, 80336 Munich, Germany. |
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Abstract: | Strenuous, anaerobic exercise leads to an increaseof leukocytes that are mobilized from the marginal pool. We haveanalyzed in human peripheral blood the effect of exercise on the number of CD14+CD16+ monocytes as determined bytwo-color immunofluorescence and flow cytometry. We show herein thatthis type of monocyte responds with a dramatic up to 4.8-fold increase.Mobilization does not occur after 1 min at 100 or 200 W but 1 min at400 W leads to a twofold increase of theCD14+CD16+ monocytes immediately afterexercise. The numbers remain high at 5 min and gradually decrease toreach the initial level at 20 min postexercise. After 20 min of rest,the CD14+CD16+ monocytes can be mobilized againby a second exercise. The CD14+CD16+ monocytesappear to be mobilized from the marginal pool where they preferentiallyhome because of a higher expression of adhesion molecules like CD11dand very late antigen-4. Exercise goes along with an increaseof catecholamines, and mobilization of theCD14+CD16+ monocytes can be substantiallyreduced by treatment of donors with the -adrenergic receptor blockerpropranolol. Mobilization of CD14+CD16+monocytes by a catecholamine-dependent mechanism may contribute to theincrease of these cells in various clinical conditions. |
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