Antimicrobial studies,synthesis and characterization of novel 1-nitro-10H-phenothiazine bearing sulfone/nucleoside moieties |
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Authors: | Dinesh Kumar Jangid Anjali Guleria Dinesh C. Gautam Hemendra Yadav Manas Mathur Ajit Kumar Swami |
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Affiliation: | 1. Department of Chemistry, University of Rajasthan, Jaipur, Rajasthan, India;2. Department of Chemistry, Malviya National Institute of Technology, Jaipur, Rajasthan, India;3. Seminal Applied Science Pvt. Ltd., Jaipur, Rajasthan, India |
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Abstract: | The current research article involves one pot synthesis of novel substituted 1-nitro-10H-phenothiazines via Smiles rearrangement. These substituted phenothiazines undergo oxidation to yield 10H-phenothiazine-5,5-dioxides (sulfones) while on treatment with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate yield ribofuranosides. These compounds were screened for their antimicrobial vitalities (in vitro) against selected strains of bacteria and fungi. The characterization of synthesized compounds was done by elemental and spectral studies. |
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Keywords: | One pot synthesis Smiles rearrangement phenothiazines sulfones ribofuranosides antimicrobial assessment |
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