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Radiofrequency radiation at 2.856 GHz does not affect key cellular endpoints in neuron-like PC12 cells
Authors:Hongmei Zhou  Guofu Dong  Wen Zheng  Shuiming Wang  Lifeng Wang  Weijia Zhi
Institution:Department of Experimental Pathology, Beijing Institute of Radiation Medicine, Beijing P. R. China
Abstract:To investigate the potential cytotoxicity of radiofrequency (RF) radiation on central nervous system, rat pheochromocytoma (PC12) cells were exposed to 2.856 GHz RF radiation at a specific absorption rate (SAR) of 4 W/kg for 8 h a day for 2 days in 35 mm Petri dishes. During exposure, the real-time variation of the culture medium temperature was monitored in the first hour. Reactive oxygen species (ROS) production, intracellular Ca2+ concentration, and cell apoptosis rate were assessed immediately after exposure by flow cytometry. The results showed that the medium temperature raised about 0.93 °C, but no significant changes were observed in apoptosis, ROS levels or intracellular Ca2+ concentration after treatment. Although several studies suggested that RF radiation does indeed cause neurological effects, this study presented inconsistent results, indicating that 2.856 GHz RF radiation exposure at a SAR of 4 W/kg does not have a dramatic impact on PC12 cells, and suggests the need for further investigation on the key cellular endpoints of other nerve cells after exposure to RF radiation.
Keywords:Radiofrequency radiation  PC12 cells  apoptosis  reactive oxygen species  Ca2+
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