Normal Insulin Sensitivity in Lean Offspring of Obese Parents |
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Authors: | Mary ACT Lazarin Joo R Bennini Carlos LC Pereira Brenno D Astiarraga Ele Ferrannini Elza Muscelli |
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Institution: | Mary A.C.T. Lazarin,João R. Bennini,Carlos L.C. Pereira,Brenno D. Astiarraga,Ele Ferrannini,Elza Muscelli |
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Abstract: | Objective: Offspring of diabetic or hypertensive patients are insulin resistant at a prediabetic/prehypertensive stage. We tested the hypothesis that insulin action may be impaired in the offspring of obese nondiabetic parents. Research Methods and Procedures: Twenty‐one lean offspring of nonobese subjects (OL) 22 ± 3 years of age] were matched to 23 lean offspring of obese subjects (OOb) by gender distribution, age, BMI, and waist circumference. Anthropometry, oral glucose tolerance, in vivo insulin sensitivity by a euglycemic insulin clamp (6 pmol/min per kilogramFFM; where FFM represents fat‐free mass)], and thermogenesis (by indirect calorimetry) were measured in each subject. The study subjects were from a population of 267 nuclear families (one offspring and both his/her parents) in which there was statistically significant (χ2 = 30.2, p = 0.001) concordance of BMI between parents and offspring. Results: In comparing OOb with OL, no statistically significant difference or trend toward a difference was detected in fasting plasma glucose and insulin concentrations, glucose and insulin responses to oral glucose, insulin sensitivity metabolism value = 45 ± 12 (OOb) vs. 47 ± 17 μmol/min per kilogramFFM (OL)], insulin‐induced inhibition of protein and lipid oxidation, stimulation of glucose oxidation and nonoxidative glucose disposal, respiratory quotient, resting energy expenditure, and glucose‐induced thermogenesis. Discussion: The metabolic similarity between lean offspring of obese parents and those of nonobese parents suggests that insulin resistance and its correlates are not co‐inherited with the predisposition to develop obesity. |
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Keywords: | offspring of obese insulin sensitivity insulin secretion insulin clamp C‐peptide |
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