The domestic goat: a useful model to determine effects of diet and exercise on cholesterol accumulation in the body

1. Young goats were used to study factors contributing to atherosclerosis. 2. Cholesterol in egg yolk affected plasma cholesterol concentration more than did a similar amount of crystalline cholesterol in the diet. 3. Goats fed high fat diets developed fatty lesions in their aortas. 4. Cholesterol concentration in low-density lipoprotein was greatest in goats fed restricted-calorie diets without exercise, but least in goats fed liberally and exercised. 5. Cholesterol concentration in liver and fat deposition in aorta were greatest in the restricted-calorie, no exercise regime.