Ideas in Theoretical Biology Origin of Cancerous Cells from Tumours |
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Authors: | Deng K. Niu Jia-Kuan Chen |
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Affiliation: | School of Life Sciences, Wuhan University, Wuhan, Hubei, China. |
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Abstract: | With a previous paper (Niu & Wang, 1995), a general, hypothetical outline of the mechanism of carcinogenesis was proposed. With reference to the fact of starvation-induced hypermutation in micro-organisms, we propose that the hypoxia commonly seen in the cells at the centre of solid tumours might also result in hypermutation, and then p53-dependent programmed cell death. Like the apparently adaptive mutations in micro-organisms, only those genes (e.g. p53) that enable the cells to escape from apoptosis may be selected. |
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