Host-determined T cell fine specificity for self-H-2 in radiation bone-marrow chimeras of standard C57BL/6 (H-2b) mutantHz1 (H-2ba), and F1 mice期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Host-determined T cell fine specificity for self-H-2 in radiation bone-marrow chimeras of standard C57BL/6 (H-2b) mutantHz1 (H-2ba), and F1 mice

Authors:	Rolf M Zinkernagel Paul A Klein Jan Klein

Institution:	(1) Department of Cellular and Developmental Immunology, Scripps Clinic and Research Foundation, 92037 La Jolla, California;(2) Department of Pathology, College of Medicine, University of Florida, 32610 Gainesville, Florida;(3) Department of Microbiology, Southwestern Medical School, University of Texas, 75235 Dallas, Texas

Abstract:	Reciprocal radiation bone-marrow chimeras were produced between the standard C57BL/6 (=B6) and the mutant B6.C-H-2 ^ba (=Hz1) strain. When infected with vaccinia virus, these chimeras, as well as an (Hz1 × B6)= Hz1 chimera, produced cytotoxic cells that killed vaccinia-infected H-2K^kH-2D^b target cells but failed to kill virus-infected H-2K^bH-2D^d cells. Virus-infected (Hz1 × B6)F₁ B6 chimeras, however, killed both types of target. These experiments demonstrate strict T-cell specificity capable of differentiating between two molecules that apparently differ by a single amino acid substitution.

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