| 复合同源异型结构的研究进展 |
| |
| 引用本文： | 周士新,孙啸,陆祖宏.复合同源异型结构的研究进展[J].遗传,2004,26(6):984-990. |
| |
| 作者姓名： | 周士新 孙啸 陆祖宏 |
| |
| 作者单位： | 东南大学分子与生物分子电子学重点实验室，南京，210096 |
| |
| 基金项目： | 国家自然科学基金，国家高技术研究发展计划(863计划) |
| |
| 摘 要： | 含有同源异型结构（homeobox）的蛋白质是一大类DNA结合蛋白，在胚胎发育、基因表达调节、细胞分化、神经发生等方面发挥重要作用。近年来发现了同源异型框与其它结构域同时存在，如PAX、POU、LIM、OAR、CUT、ELK、bZIP、SIX、PHD-finger、Engrailed等，近来还发现它通过基因融合或基因失调控方式参与肿瘤的发生。本文对这些含有复合同源框的蛋白质和基因的类型、结构、功能等方面的研究进展进行综述。
|
| 关 键 词： | 基因融合 基因失调控 DNA结合蛋白 同源框 |
| 文章编号： | 0253-9772(2004)06-0984-07 |
| 修稿时间： | 2003年12月31 |
The Progress in Complex Homeobox Domains |
| |
| ZHOU Shi-Xin,SUN Xiao,LU Zu-Hong.The Progress in Complex Homeobox Domains[J].Hereditas,2004,26(6):984-990. |
| |
| Authors: | ZHOU Shi-Xin SUN Xiao LU Zu-Hong |
| |
| Institution: | Key Laboratory of Molecular and Biomolecular Electronics of Ministry of Education, Southeast University, Nanjing 210096,China |
| |
| Abstract: | The proteins with 'homeobox' (HOX) domain, a large family of DNA binding, play an important role in embryonic development, gene regulation, cell differentiation and neurogenesis. Some other domains are found in the proteins together with HOX, such as PAX, POU, LIM, OAR, ELK, SIX, bZIP, PHD-finger, Engrailed, hexapeptide domains. The HOX combined with other domains that associate with DNA binding or protein interactions are called 'complex homeobox'. Recent reports indicate that 'complex homeobox' genes also take part in tumorigenesis by the way of gene fusions and deregulation. The progress of 'complex homeobox' in types, structures and functions have been summarized in this review. |
| |
| Keywords: | homeobox domain DNA binding proteins deregulation of genes gene fusions |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《遗传》浏览原始摘要信息 |
| 点击此处可从《遗传》下载免费的PDF全文 |
|
