Thermodynamics of ATP hydrolysis from membrane electrode measurements of metal-ion ATP and ADP complexation |
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| Authors: | E J Fogt G A Rechnitz |
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| Affiliation: | Department of Chemistry, State University of New York, Buffalo, New York 14214 U.S.A. |
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| Abstract: | Free energies for the ATP-ADP hydrolysis reaction have been recalculated on the basis of new thermodynamic formation constants for metal-ion ATP and ADP complexes as determined by potentiometric measurements with ion-selective membrane electrodes. It is shown that free-energy maps are sharply altered at metal-ion levels greater than 10?3m because of the effect of previously unrecognized 2:1 complexes of divalent metal ions with ATP and ADP. New formation constants for ADP complexes with sodium, potassium, calcium, and magnesium are also reported. |
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