A HLA-Cw*0701 restricted Melan-A/MART1 epitope presented by melanoma tumor cells to CD8+ tumor infiltrating lymphocytes |
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Authors: | Pierre Larrieu Virginie Renaud Yann Godet Francine Jotereau Jean-François Fonteneau |
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Affiliation: | (1) INSERM U601, Institut de biologie, 9 quai moncousu, 44093 Nantes Cedex, France;(2) Université de Nantes, 44322 Nantes, France |
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Abstract: | Melan-A/MART1 is a melanocytic differentiation antigen recognized on melanoma tumor cells by CD8+ and CD4+ T cells. In this study, we describe a new epitope of this protein recognized in the context of HLA-Cw*0701 molecules by a CD8+ tumor infiltrating lymphocyte (TIL) clone. This CD8+ TIL clone specifically recognized and killed a fraction of melanoma cells lines expressing Melan-A/MART1 and HLA-Cw*0701. We further show that the Melan-A/MART151–61 peptide is the optimal peptide recognized by this clone. Together, these data significantly enlarge the fraction of melanoma patients susceptible to benefit from a Melan-A/MART1 vaccine approach. |
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Keywords: | CD8+ T cells Cancer Melanoma Melan-A/MART1 HLA-Cw*0701 |
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