Tet Proteins Connect the O-Linked N-acetylglucosamine Transferase Ogt to Chromatin in Embryonic Stem Cells期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Tet Proteins Connect the O-Linked N-acetylglucosamine Transferase Ogt to Chromatin in Embryonic Stem Cells

Authors:	Pietro Vella Andrea Scelfo SriGanesh Jammula Fulvio Chiacchiera Kristine Williams Alessandro Cuomo Alessandra Roberto Jesper Christensen Tiziana Bonaldi Kristian Helin Diego Pasini

Institution:	1. Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy;2. Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark;3. Centre for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark;4. The Danish Stem Cell Centre, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark

Abstract:	Download : Download high-res image (107KB) Download : Download full-size image Highlights? Ogt forms a complex with Tet1 and Tet2 in the nucleus of embryonic stem cells ? Ogt preferentially associates with promoter regions in proximity of TSS ? Ogt shows >90% of colocalization with Tet1 at methylation-free CpG-rich elements ? Tet1 is required for global Ogt chromatin recruitment regulating its activity

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