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Histone Acetylation Regulates Intracellular pH
Authors:Matthew A McBrian  Iman Saramipoor Behbahan  Roberto Ferrari  Trent Su  Ta-Wei Huang  Kunwu Li  Candice S Hong  Heather R Christofk  Maria Vogelauer  David B Seligson  Siavash K Kurdistani
Institution:1. Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA;2. Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA;3. Division of Oral Biology and Medicine, School of Dentistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA;4. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA;5. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA;6. Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
Abstract:
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  • Highlights? Global levels of histone acetylation change in response to pHi alterations ? Histone deacetylation and acetate transport through H+-coupled MCTs regulates pHi ? Proliferation of T cells results in increases in pHi and global histone acetylation ? HDAC and MCT inhibitors decrease pHi
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