Analysis of the impact of ERK5, JNK,and P38 kinase cascades on each other: A systems approach |
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Authors: | Pandurangan Sundaramurthy Sunita Gakkhar Ramanathan Sowdhamini |
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Institution: | 1.Department of Mathematics, Indian Institute of Technology Roorkee, Roorkee - 247667, Uttarakhand, India;2.National Center for Biological Sciences, Tata Institute of Fundamental Research, UAS-GKVK campus, Bellary Road, Bangalore - 560 065, India |
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Abstract: | The classical concept of linear pathways is being increasingly challenged by network representations, which emphasize the
importance of interactions between components of a biological system, and motivates for adopting a system‐level approach in
biology. We have developed a dynamical system that integrates quantitative, dynamic and topological representation of network of
ERK5 (Extracellular signal‐regulated kinases 5), JNK(c‐Jun N‐terminal kinases) and P38 kinase cascades. We have observered that,
the transient activation of ERK5, JNK1 and P38β kinase, and the persistent activation of JNK2, JNK3 and P38 δ
kinase does not get affected due to the cross‐talks between ERK5, JNK and P38 kinase cascades. But it is due to the cross ‐ talks,
the transiently activated P38α kinase become inactivated, and the transiently activated P38γ kinase become
persistently activated. The impacts of one‐way cross‐talks between the cascades are insignificant and differ from the impact of
two‐way cross‐talks. We generate a hypothesis that, signaling pathways should be studied as a system by considering the
cross‐talks between the two adjacent cascades. |
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Keywords: | cross‐ talks ERK5 JNK P38 kinase cascades systems approach |
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