CRL1-FBXO11 Promotes Cdt2 Ubiquitylation and Degradation and Regulates Pr-Set7/Set8-Mediated Cellular Migration期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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CRL1-FBXO11 Promotes Cdt2 Ubiquitylation and Degradation and Regulates Pr-Set7/Set8-Mediated Cellular Migration

Authors:	Tarek Abbas Adam C Mueller Etsuko Shibata Mignon Keaton Mario Rossi Anindya Dutta

Institution:	1. Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA;2. Department of Radiation Oncology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA;3. Instituto de Investigación Biomedicina de Buenos Aires (IBioBA)-CONICET-Partner Institute of the Max Planck Society, Godoy Cruz 2390, C1425FQA Buenos Aires, Argentina

Abstract:	Download : Download high-res image (98KB) Download : Download full-size image Highlights? Cullin 4A promotes the autoubiquitylation of Cdt2, a substrate adaptor of CRL4^Cdt2 ? CRL1^FBXO11 also ubiquitylates and promotes the degradation of Cdt2 ? FBXO11 degrades Cdt2 to stabilize Set8 and regulate the response to TGF-β ? FBXO11 is similarly required to stabilize Set8 and promote cell migration

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