A Genome-wide RNAi Screen Reveals a Trio-Regulated Rho GTPase Circuitry Transducing Mitogenic Signals Initiated by G Protein-Coupled Receptors期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

A Genome-wide RNAi Screen Reveals a Trio-Regulated Rho GTPase Circuitry Transducing Mitogenic Signals Initiated by G Protein-Coupled Receptors

Authors:	Jose P. Vaqué,Robert T. Dorsam,Xiaodong Feng,Ramiro Iglesias-Bartolome,David J. Forsthoefel,Qianming Chen,Anne Debant,Mark A. Seeger,Bruce R. Ksander,Hidemi Teramoto,J. Silvio Gutkind

Affiliation:	1. Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4340, USA;2. Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA;3. State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan 610041, China;4. Department of Molecular Genetics, Ohio State University, Columbus, OH 43210-1292, USA;5. Centre de Recherche de Biochimie Macromoléculaire, CNRS, UMR 5237, Universités de Montpellier I et II,1919 Route de Mende, 34293 Montpellier Cedex 5, France;6. Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA;7. Kojin Hospital, Nagoya 463-8530, Japan

Abstract:	Download : Download high-res image (239KB) Download : Download full-size image Highlights? Human cancers harbor frequent mutations in Gq-linked GPCRs and Gα_q subunits ? A genome-wide RNAi screen revealed that Trio is essential for activating AP-1 via Gα_q ? A network of Trio-regulated Rho GTPases and MAPKs links Gq to the nucleus ? A hard-wired Gq-Trio signaling axis promotes the growth of many human malignancies

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