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LSD2/KDM1B and Its Cofactor NPAC/GLYR1 Endow a Structural and Molecular Model for Regulation of H3K4 Demethylation
Authors:Rui Fang  Fei Chen  Zhenghong Dong  Di Hu  Andrew J Barbera  Erin A Clark  Jian Fang  Ying Yang  Pinchao Mei  Michael Rutenberg  Ze Li  Ying Zhang  Youwei Xu  Huirong Yang  Ping Wang  Matthew D Simon  Qiongjie Zhou  Jing Li  Yujiang Geno Shi
Institution:1. Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine and Department of Biological Chemistry & Molecular Pharmacology, Brigham and Women’s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA;2. Institutes of Biomedical Sciences, Fudan University, 130 Dong An Road, Shanghai 200032, China;3. Department of Chemistry, Fudan University, 130 Dong An Road, Shanghai 200032, China;4. State Key Laboratory of Genetic Engineering, Fudan University, 130 Dong An Road, Shanghai 200032, China;5. Obstetrics and Gynecology Hospital, Fudan University, 130 Dong An Road, Shanghai 200032, China;6. Children’s Hospital, Fudan University, 130 Dong An Road, Shanghai 200032, China;7. Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Abstract:
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  • Highlights? Identifying NPAC as a novel LSD2 cofactor stimulating H3K4 demethylation ? Structure determination of LSD2 alone or in complex with NPAC and histone H3 peptide ? Defining the key NPAC residues essential for its intrinsic LSD2 cofactor activity ? Establishing a molecular model for how a cofactor regulates histone demethylation
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